Altered Cardiovascular Defense to Hypotensive Stress in the Chronically Hypoxic Fetus.

ABSTRACT: The hypoxic fetus is at greater risk of cardiovascular demise during a challenge, but the reasons behind this are unknown. Clinically, progress has been hampered by the inability to study the human fetus non-invasively for long period of gestation. Using experimental animals, there has also been an inability to induce gestational hypoxia while recording fetal cardiovascular function as the hypoxic pregnancy is occurring. We use novel technology in sheep pregnancy that combines induction of controlled chronic hypoxia with simultaneous, wireless recording of blood pressure and blood flow signals from the fetus. Here, we investigated the cardiovascular defense of the hypoxic fetus to superimposed acute hypotension. Pregnant ewes carrying singleton fetuses surgically prepared with catheters an

SUBMITTER: Allison BJ 

PROVIDER: S-EPMC7480941 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature