Combined gas embolization and chemotherapy can result in complete tumor regression in a murine hepatocellular carcinoma model.

ABSTRACT: Hepatocellular carcinoma (HCC) is an intractable cancer with a high mortality rate. Transarterial chemoembolization (TACE), a non-curative method, is the first line therapy for intermediate stage patients. This effectively extends patient survival but requires a complicated intraarterial catheterization procedure and is poorly suited to repeated administration. Here, we investigate gas chemoembolization, a less invasive, more easily administered transient occlusion method that circumvents these limitations. We examined the efficacy of repeated embolization combined with systemically administered doxorubicin, the most common chemotherapeutic in TACE, or tirapazamine, a hypoxia-activated cytotoxic agent, in an ectopic xenograft model of HCC. Emboli were generated in situ using acousti

SUBMITTER: Harmon JS 

PROVIDER: S-EPMC7481009 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature