Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery.

ABSTRACT: The strategies concerning modification of the complex immune pathological inflammatory environment during acute spinal cord injury remain oversimplified and superficial. Inspired by the acidic microenvironment at acute injury sites, a functional pH-responsive immunoregulation-assisted neural regeneration strategy was constructed. With the capability of directly responding to the acidic microenvironment at focal areas followed by triggered release of the IL-4 plasmid-loaded liposomes within a few hours to suppress the release of inflammatory cytokines and promote neural differentiation of mesenchymal stem cells in vitro, the microenvironment-responsive immunoregulatory electrospun fibers were implanted into acute spinal cord injury rats. Together with sustained release of nerve growth facto

SUBMITTER: Xi K 

PROVIDER: S-EPMC7481196 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature