Ontology highlight
ABSTRACT:
SUBMITTER: Cioni B
PROVIDER: S-EPMC7481219 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Nature communications 20200909 1
The androgen receptor (AR) is the master regulator of prostate cancer (PCa) development, and inhibition of AR signalling is the most effective PCa treatment. AR is expressed in PCa cells and also in the PCa-associated stroma, including infiltrating macrophages. Macrophages have a decisive function in PCa initiation and progression, but the role of AR in macrophages remains largely unexplored. Here, we show that AR signalling in the macrophage-like THP-1 cell line supports PCa cell line migration ...[more]