Granulocytic Myeloid-Derived Suppressor Cells as Negative Regulators of Anticancer Immunity.

ABSTRACT: The immune system plays a critical role in cancer progression and response to therapy. However, the immune system can be compromised during the neoplastic process. Notably, the myeloid lineage, which gives rise to granulocytic cells, including neutrophils, is a well-recognized target of tumor-mediated immune suppression. Ordinarily, granulocytic cells are integral for host defense, but in neoplasia the normal process of granulocyte differentiation (i.e., granulopoiesis) can be impaired leading instead to the formation of granulocytic (or PMN)-myeloid-derived suppressor cells (MDSCs). Such cells comprise various stages of myeloid differentiation and are defined functionally by their highly pro-tumorigenic and immune suppressive activities. Thus, considerable interest has been devoted to imp

SUBMITTER: Kramer ED 

PROVIDER: S-EPMC7481329 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature