Phenotypic Variability in a Coinfection With Three Independent Candida parapsilosis Lineages.

ABSTRACT: The human pathogenic yeast Candida parapsilosis has gained significant importance over the past decades as one of the principal causes of fungal bloodstream infections. Isolates of C. parapsilosis are known to be able to switch between several different colony morphologies in vitro, which are correlated with different cell shapes, altered cell surface properties, and thus different capacities to form biofilms on indwelling medical devices. In a set of six clinical specimens from a single surgery patient yielding stable smooth- as well as crepe-morphology isolates, we investigated the differences between five of them on a phenotypic and genomic level. In contrast to the initial assumption that they were switched forms of a clonal strain, karyotyping and genome sequencing showe

SUBMITTER: Gomez-Molero E 

PROVIDER: S-EPMC7481391 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature