LAMA4 upregulation is associated with high liver metastasis potential and poor survival outcome of Pancreatic Cancer.

ABSTRACT: Rationale: Pancreatic cancer is one of the most difficult cancers to manage and its poor prognosis stems from the lack of a reliable early disease biomarker coupled with its highly metastatic potential. Liver metastasis accounts for the high mortality rate in pancreatic cancer. Therefore, a better understanding of the mechanism(s) underlying the acquisition of the metastatic potential in pancreatic cancer is highly desirable. Methods: Microarray analysis in wild-type and highly liver metastatic human pancreatic cancer cell lines was performed to identify gene expression signatures that underlie the metastatic process. We validated our findings in patient samples, nude mice, cell lines and database analysis. Results: We identified a metastasis-related gene, laminin subu

SUBMITTER: Zheng B 

PROVIDER: S-EPMC7481422 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature