TRPV4-Mediated Regulation of the Blood Brain Barrier Is Abolished During Inflammation.

ABSTRACT: Blood-brain barrier (BBB) dysfunction is critically involved in determining the extent of several central nervous systems (CNS) pathologies and here in particular neuroinflammatory conditions. Inhibiting BBB breakdown could reduce the level of vasogenic edema and the number of immune cells invading the CNS, thereby counteracting neuronal injury. Transient receptor potential (TRP) channels have an important role as environmental sensors and constitute attractive therapeutic targets that are involved in calcium homeostasis during pathologies of the CNS. Transient receptor potential vanilloid 4 (TRPV4) is a calcium permeable, non-selective cation channel highly expressed in endothelial cells. As it is involved in the regulation of the blood brain barrier permeability and consequently cerebral

SUBMITTER: Rosenkranz SC 

PROVIDER: S-EPMC7481434 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature