Predictive and prognostic significance of M descriptors of the 8th TNM classification for advanced NSCLC patients treated with immune checkpoint inhibitors.

ABSTRACT:

Background

A strong association between M descriptors and prognosis of non-small cell lung cancer (NSCLC) has been demonstrated recently. However, its predictive and prognostic significance for advanced NSCLC patients treated with immune checkpoint inhibitors (ICIs) remain unclear. In this study, we aimed at investigating the impact of M descriptors on clinical outcomes in those patients.

Methods

A retrospective analysis was conducted. Patients treated with more than two cycles of ICIs were included. Detailed characteristics and clinical response after immunotherapy were recorded. M descriptors were classified into M1a, M1b, and M1c according to the 8th TNM classification.

Results

A total of 103 patients were enrolled, including 42 with M1a disease, 16 with M1b diseas

SUBMITTER: Liu S 

PROVIDER: S-EPMC7481592 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature