Comprehensive serial biobanking in advanced NSCLC: feasibility, challenges and perspectives.

ABSTRACT:

Background

Availability of tumor material at baseline and disease progression is increasingly important for patient management in non-small-cell lung cancer (NSCLC), especially for the application of targeted therapies like tyrosine kinase inhibitors and for immune checkpoint inhibitor treatment. Here we report the experience of prospective biomaterial acquisition in advanced NSCLC from a pilot project.

Methods

Main objective was the longitudinal collection of high-quality, cryoconserved biopsies in addition to formalin-fixed paraffin-embedded (FFPE) biopsies required for routine diagnostics, along with blood samples and detailed clinical annotation using standardized questionnaires.

Results

Over five years, 205 patients were enrolled for the project, yielding 387 cry

SUBMITTER: Wessels S 

PROVIDER: S-EPMC7481602 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature