Molecular differences across invasive lung adenocarcinoma morphological subgroups.

ABSTRACT:

Background

Lung adenocarcinomas (ADCs) show heterogeneous morphological patterns that are classified into five subgroups: lepidic predominant, papillary predominant, acinar predominant, micropapillary predominant and solid predominant. The morphological classification of ADCs has been reported to be associated with patient prognosis and adjuvant chemotherapy response. However, the molecular mechanisms underlying the morphology differences among different subgroups remain largely unknown.

Methods

Using the molecular profiling data from The Cancer Genome Atlas (TCGA) lung ADC (LUAD) cohort, we studied the molecular differences across invasive ADC morphological subgroups.

Results

We showed that the expression of proteins and mRNAs, but not the gene mutations copy number

SUBMITTER: Ci B 

PROVIDER: S-EPMC7481608 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature