Genetic and microenvironmental differences in non-smoking lung adenocarcinoma patients compared with smoking patients.

ABSTRACT:

Background

Non-smoking-related lung adenocarcinoma (LUAD) has its own characteristics. Genetic and microenvironmental differences in smoking and non-smoking LUAD patients were analyzed to elucidate the oncogenesis of non-smoking-related LUAD, which will improve our understanding of the underlying molecular mechanism and be of clinical use in the future.

Methods

The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) databases were used for clinical and genomic information. Various bioinformatics tools were used to analyze differences in somatic mutations, RNA and microRNA (miRNA) expression, immune infiltration, and stemness indices. GO, KEGG, and GSVA analyses were performed with R. A merged protein-protein interaction (PPI) network was constructed and analyzed. A miR

SUBMITTER: Sui Q 

PROVIDER: S-EPMC7481643 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature