Modelling cytoskeletal transport by clusters of non-processive molecular motors with limited binding sites.

ABSTRACT: Molecular motors are responsible for intracellular transport of a variety of biological cargo. We consider the collective behaviour of a finite number of motors attached on a cargo. We extend previous analytical work on processive motors to the case of non-processive motors, which stochastically bind on and off cytoskeletal filaments with a limited number of binding sites available. Physically, motors attached to a cargo cannot bind anywhere along the filaments, so the number of accessible binding sites on the filament should be limited. Thus, we analytically study the distribution and the velocity of a cluster of non-processive motors with limited number of binding sites. To validate our analytical results and to go beyond the level of detail possible analytically, we perform Monte Carlo

SUBMITTER: Rueangkham N 

PROVIDER: S-EPMC7481682 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature