Genome-wide methylation data from R1 (wild-type) and the transgenic Dnmt1^Tet/Tet mouse embryonic stem cells overexpressing DNA methyltransferase 1 (DNMT1).

ABSTRACT: Defects in epigenetic mechanisms are well-recognized in multiple neurodevelopmental disorders including Schizophrenia (SZ). In addition to aberrant epigenetic marks, dysregulated epigenetic machinery was also identified among the contributory factors in SZ patients. Among these, overexpression of DNA methyltransferase 1 (DNMT1) was the first to be identified. In this context, Dnmt1^tet/tet (Tet/Tet), a mouse embryonic stem cell (ESC) line that overexpresses DNMT1 in ESCs and neurons, was developed to study abnormal neurogenesis. In an attempt to understand whether DNMT1 overexpression is associated with aberrant DNA methylation, we compared the genome-wide methylation levels of R1 (wild-type) and Tet/Tet ESCs and their neuronal derivatives by RRBS. The

SUBMITTER: Saxena S 

PROVIDER: S-EPMC7481814 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature