Systematic review of extracellular vesicle-based treatments for lung injury: are EVs a potential therapy for COVID-19?

ABSTRACT: Severe COVID-19 infection results in bilateral interstitial pneumonia, often leading to acute respiratory distress syndrome (ARDS) and pulmonary fibrosis in survivors. Most patients with severe COVID-19 infections who died had developed ARDS. Currently, ARDS is treated with supportive measures, but regenerative medicine approaches including extracellular vesicle (EV)-based therapies have shown promise. Herein, we aimed to analyse whether EV-based therapies could be effective in treating severe pulmonary conditions that affect COVID-19 patients and to understand their relevance for an eventual therapeutic application to human patients. Using a defined search strategy, we conducted a systematic review of the literature and found 39 articles (2014-2020) that reported effects of EVs, mainly de

SUBMITTER: Khalaj K 

PROVIDER: S-EPMC7481829 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature