SIRT5 Contributes to Colorectal Cancer Growth by Regulating T Cell Activity.

ABSTRACT: Over the past several years, SIRT5 has attracted considerable attention in metabolic regulation. However, the function of SIRT5 in tumorigenesis by regulating tumor microenvironment is poorly understood. In this work, we found that Sirt5 knockout mice were resistant to AOM and DSS-induced colitis-associated colorectal tumorigenesis and the level of IFN-γ in their tumor microenvironment was higher. Additionally, proteome and network analysis revealed that SIRT5 was important in the T cell receptor signaling pathway. Furthermore, we determined that a deficiency of Sirt5 induced stronger T cell activation and demonstrated that SIRT5 played a pivotal role in regulating the differentiation of CD4⁺ regulatory T (Treg) cells and T helper 1 (Th1) cells. An imbalance

SUBMITTER: Wang K 

PROVIDER: S-EPMC7481950 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature