Telomere Shortening in the Alzheimer's Disease Neuroimaging Initiative Cohort.

ABSTRACT:

Background

Although shorter telomeres have been associated with Alzheimer's disease (AD), it is unclear whether longitudinal change in telomere length is associated with AD progression.

Objective

To investigate the association of telomere length change with AD diagnosis and progression.

Methods

In 653 individuals from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort, T/S ratio (telomere versus single copy gene), a proxy of telomere length, was measured for up to five visits per participant (N = 1918 samples post-QC) using quantitative PCR (qPCR). T/S ratio was adjusted for batch effects and DNA storage time. A mixed effects model was used to evaluate association of telomere length with AD diagnostic group and interaction of age and diagnosis. Another mixe

SUBMITTER: Nudelman KNH 

PROVIDER: S-EPMC7481955 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature