Prebiotics and Community Composition Influence Gas Production of the Human Gut Microbiota.

ABSTRACT: Prebiotics confer benefits to human health, often by promoting the growth of gut bacteria that produce metabolites valuable to the human body, such as short-chain fatty acids (SCFAs). While prebiotic selection has strongly focused on maximizing the production of SCFAs, less attention has been paid to gases, a by-product of SCFA production that also has physiological effects on the human body. Here, we investigate how the content and volume of gas production by human gut microbiota are affected by the chemical composition of the prebiotic and the community composition of the microbiota. We first constructed a linear system model based on mass and electron balance and compared the theoretical product ranges of two prebiotics, inulin and pectin. Modeling shows that pectin is more restricted i

SUBMITTER: Yu X 

PROVIDER: S-EPMC7482059 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature