How the Anaerobic Enteropathogen Clostridioides difficile Tolerates Low O2 Tensions.
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ABSTRACT: Clostridioides difficile is a major cause of diarrhea associated with antibiotherapy. After germination of C. difficile spores in the small intestine, vegetative cells are exposed to low oxygen (O2) tensions. While considered strictly anaerobic, C. difficile is able to grow in nonstrict anaerobic conditions (1 to 3% O2) and tolerates brief air exposure indicating that this bacterium harbors an arsenal of proteins involved in O2 detoxification and/or protection. Tolerance of C. difficile to low O2 tensions requires the presence of the alternative sigma factor, σB, involved in the general stress response. Among the genes positively controlled by σB, four encode proteins likely involved in O2
SUBMITTER: Kint N
PROVIDER: S-EPMC7482061 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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