Laccase Affects the Rate of Cryptococcus neoformans Nonlytic Exocytosis from Macrophages.

ABSTRACT: Nonlytic exocytosis is a process in which previously ingested microbes are expelled from host phagocytes with the concomitant survival of both cell types. This process has been observed in the interaction of Cryptococcus spp. and other fungal cells with phagocytes as distant as mammalian, bird, and fish macrophages and ameboid predators. Despite a great amount of research dedicated to unraveling this process, there are still many questions about its regulation and its final benefits for host or fungal cells. During a study to characterize the virulence attributes of Brazilian clinical isolates of C. neoformans, we observed great variability in their rates of nonlytic exocytosis and noted a correlation between this process and fungal melanin production/laccase activity. Flow c

SUBMITTER: Frazao SO 

PROVIDER: S-EPMC7482070 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature