Dataset Information

The Mixture of Autoregressive Hidden Markov Models of Morphology for Dentritic Spines During Activation Process.

ABSTRACT: The dendritic spines play a crucial role in learning and memory processes, epileptogenesis, drug addiction, and postinjury recovery. The shape of the dendritic spine is a morphological key to understand learning and memory process. The classification of the dendritic spines is based on their shapes but the major questions are how the shapes changes in time, how the synaptic strength changes, and is there a correlation between shapes and synaptic strength? Because the changes of the classes by dendritic spines during activation are time dependent, the forward-directed autoregressive hidden Markov model (ARHMM) can be used to model these changes. It is also more appropriate to use an ARHMM directed backward in time. Thus, the mixture of forward-directed ARHMM and backward-directed ARHMM (MARHMM) is used to model time-dependent data related to the dendritic spines. In this article, we discuss (1) how to choose the initial probability vector and transition and dependence matrices in ARHMM and MARHMM for modeling the dendritic spines changes and (2) how to estimate these matrices. Many descriptors to classify dendritic spines in two-dimensional or/and three-dimensional (3D) are available. Our results from sensitivity analysis show that the classification that comes from 3D descriptors is closer to the truth, and estimated transition and dependence probability matrices are connected with the molecular mechanism of the dendritic spines activation.

SUBMITTER: Urban P

PROVIDER: S-EPMC7482113 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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The Mixture of Autoregressive Hidden Markov Models of Morphology for Dentritic Spines During Activation Process.

Urban Paulina P Rezaei Tabar Vahid V Denkiewicz Michał M Bokota Grzegorz G Das Nirmal N Basu Subhadip S Plewczynski Dariusz D

Journal of computational biology : a journal of computational molecular cell biology 20200312 9

The dendritic spines play a crucial role in learning and memory processes, epileptogenesis, drug addiction, and postinjury recovery. The shape of the dendritic spine is a morphological key to understand learning and memory process. The classification of the dendritic spines is based on their shapes but the major questions are how the shapes changes in time, how the synaptic strength changes, and is there a correlation between shapes and synaptic strength? Because the changes of the classes by de ...[more]

PMID: 32175768

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Project description:BackgroundRiboswitches are a type of noncoding RNA that regulate gene expression by switching from one structural conformation to another on ligand binding. The various classes of riboswitches discovered so far are differentiated by the ligand, which on binding induces a conformational switch. Every class of riboswitch is characterized by an aptamer domain, which provides the site for ligand binding, and an expression platform that undergoes conformational change on ligand binding. The sequence and structure of the aptamer domain is highly conserved in riboswitches belonging to the same class. We propose a method for fast and accurate identification of riboswitches using profile Hidden Markov Models (pHMM). Our method exploits the high degree of sequence conservation that characterizes the aptamer domain.ResultsOur method can detect riboswitches in genomic databases rapidly and accurately. Its sensitivity is comparable to the method based on the Covariance Model (CM). For six out of ten riboswitch classes, our method detects more than 99.5% of the candidates identified by the much slower CM method while being several hundred times faster. For three riboswitch classes, our method detects 97-99% of the candidates relative to the CM method. Our method works very well for those classes of riboswitches that are characterized by distinct and conserved sequence motifs.ConclusionRiboswitches play a crucial role in controlling the expression of several prokaryotic genes involved in metabolism and transport processes. As more and more new classes of riboswitches are being discovered, it is important to understand the patterns of their intra and inter genomic distribution. Understanding such patterns will enable us to better understand the evolutionary history of these genetic regulatory elements. However, a complete picture of the distribution pattern of riboswitches will emerge only after accurate identification of riboswitches across genomes. We believe that the riboswitch detection method developed in this paper will aid in that process. The significant advantage in terms of speed, of our pHMM-based approach over the method based on CM allows us to scan entire databases (rather than 5'UTRs only) in a relatively short period of time in order to accurately identify riboswitch candidates.

Dataset Information

The Mixture of Autoregressive Hidden Markov Models of Morphology for Dentritic Spines During Activation Process.

Publications

The Mixture of Autoregressive Hidden Markov Models of Morphology for Dentritic Spines During Activation Process.

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