Pace and stability of embryonic development affect telomere dynamics: an experimental study in a precocial bird model.

ABSTRACT: Prenatal effects on telomere length are increasingly recognized as a potential contributor to the developmental origin of health and adult disease. While it is becoming clear that telomere length is influenced by prenatal conditions, the factors affecting telomere dynamics during embryogenesis remain poorly understood. We manipulated both the pace and stability of embryonic development through varying incubation temperature and its stability in Japanese quail. We investigated the impact on telomere dynamics from embryogenesis to adulthood, together with three potential drivers of telomere shortening, growth rate, oxidative damage and prenatal glucocorticoid levels. Telomere length was not affected by our prenatal manipulation for the first 75% of embryogenesis, but was reduced at hatching

SUBMITTER: Stier A 

PROVIDER: S-EPMC7482268 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature