Past, Present, and Future of Remdesivir: An Overview of the Antiviral in Recent Times.

ABSTRACT: In the current COVID-19 pandemic, evidence to justify the use of any specific antiviral drug with proven efficacy is not yet available. Antiviral drug development always remains a challenge to the scientists. Remdesivir has emerged as a promising molecule, based on results of clinical trials and observational studies and has receieved marketing approval for COVID-19 treatment under "emergency use authorization" in countries such as United States. Remdesivir is a newer antiviral drug that acts as an RNA-dependent RNA polymerase (RdRp) inhibitor targeting the viral genome replication process. Therapeutic efficacy was first demonstrated by suppressing viral replication in Ebola-infected rhesus monkeys. It is available for parenteral use with reasonable safety and tolerability profile. Multipl

SUBMITTER: Choudhury S 

PROVIDER: S-EPMC7482359 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature