Elucidating the Molecular Interactions of Chemokine CCL2 Orthologs with Flavonoid Baicalin.

ABSTRACT: An integrated and controlled migration of leukocytes is necessary for the legitimate functioning and maintenance of the immune system. Chemokines and their receptors play a decisive role in regulating the leukocyte migration to the site of inflammation, a phenomena often referred to as chemotaxis. Chemokines and their receptors have become significant targets for therapeutic intervention considering their potential to regulate the immune system. Monocyte chemoattractant protein-1 (MCP-1/CCL2) is a preeminent member of CC chemokine family that facilitates crucial roles by orchestrating the recruitment of monocytes into inflamed tissues. Baicalin (BA), a major bioactive flavonoid, has been reported to attenuate chemokine-regulated leukocyte trafficking. However, no molecular details pertaini

SUBMITTER: Joshi N 

PROVIDER: S-EPMC7482410 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature