Vaccine safety surveillance informs public health policy beyond immunization: A case-series on bleeding following vaccination, Nepal, 2016-2018.

ABSTRACT:

Background

Surveillance for adverse events following immunization (AEFI) is important to monitor vaccine safety and should lead to appropriate responses to improve health and immunization program. Bleeding following vaccination is not recognized as an important AEFI. Without policy of vitamin K (VK) prophylaxis at birth, vitamin K deficiency bleeding (VKDB) could be an important cause of bleeding in young infants and may manifest as AEFI.

Methods

We retrospectively analysed all serious AEFI cases that presented with external or internal bleeding reported to Nepal's AEFI surveillance system during 2016-2018. The cases were classified as VKDB, suspected VKDB or non-VKDB.

Results

During the period, 16 serious AEFI with symptom or sign of bleeding were reported representi

SUBMITTER: Pradhan R 

PROVIDER: S-EPMC7482439 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature