Fly-Tox: A panel of transgenic flies expressing pest and pollinator cytochrome P450s.

ABSTRACT: There is an on-going need to develop new insecticides that are not compromised by resistance and that have improved environmental profiles. However, the cost of developing novel compounds has increased significantly over the last two decades. This is in part due to increased regulatory requirements, including the need to screen both pest and pollinator insect species to ensure that pre-existing resistance will not hamper the efficacy of a new insecticide via cross-resistance, or adversely affect non-target insect species. To add to this problem the collection and maintenance of toxicologically relevant pest and pollinator species and strains is costly and often difficult. Here we present Fly-Tox, a panel of publicly available transgenic Drosophila melanogaster lines each containing one or

SUBMITTER: McLeman A 

PROVIDER: S-EPMC7482442 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature