Computational and experimental investigation of particulate matter deposition in cerebral side aneurysms.

ABSTRACT: Intracranial aneurysms frequently develop blood clots, plaque and inflammations, which are linked to enhanced particulate mass deposition. In this work, we propose a computational model for particulate deposition, that accounts for the influence of field forces, such as gravity and electrostatics, which produce an additional flux of particles perpendicular to the fluid motion and towards the wall. This field-mediated flux can significantly enhance particle deposition in low-shear environments, such as in aneurysm cavities. Experimental investigation of particle deposition patterns in in vitro models of side aneurysms, demonstrated the ability of the model to predict enhanced particle adhesion at these sites. Our results showed a significant influence of gravity and electrostatic for

SUBMITTER: Epshtein M 

PROVIDER: S-EPMC7482554 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature