Overexpression of KIAA1199 is an independent prognostic marker in laryngeal squamous cell carcinoma.

ABSTRACT:

Background

KIAA1199 is a recently identified novel gene that is upregulated in various human cancers with poor survival, but its role and the underlying mechanisms in laryngeal squamous cell carcinoma (LSCC) remain unknown. Here, we collected tissues from 105 cases of LSCC to investigate the relationships between KIAA1199 protein expression and clinical factors.

Methods

Western blotting and real-time quantitative PCR (RT-PCR) were used for detect the protein and mRNA expression of KIAA1199 in LSCC tissue. Immunohistochemistry (IHC) staining was used to detect the expression of KIAA1199. Patient clinical information, for instance sex, age, pathological differentiation, clinical region, T stage, N stage, clinical stage, operation type, neck lymph dissection, smoking status, an

SUBMITTER: Huang M 

PROVIDER: S-EPMC7482636 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature