Metabolic cooperativity between Porphyromonas gingivalis and Treponema denticola.

ABSTRACT:

Background

 Porphyromonas gingivalis and Treponema denticola are proteolytic periodontopathogens that co-localize in polymicrobial subgingival plaque biofilms, display in vitro growth symbiosis and synergistic virulence in animal models of disease. These symbioses are underpinned by a range of metabolic interactions including cooperative hydrolysis of glycine-containing peptides to produce free glycine, which T. denticola uses as a major energy and carbon source.

Objective

 To characterize the P. gingivalis gene products essential for these interactions. Methods: The P. gingivalis transcriptome exposed to cell-free T. denticola conditioned medium was determined using RNA-seq. P. gingivalis proteases potentially involved

SUBMITTER: Kin LX 

PROVIDER: S-EPMC7482830 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature