Indirect pathological indicators for cardiac sarcoidosis on endomyocardial biopsy.

ABSTRACT:

Background

The definitive pathologic diagnosis of cardiac sarcoidosis requires observation of a granuloma in the myocardial tissue. It is common, however, to receive a "negative" report for a clinically probable case. We would like to advise pathologists and clinicians on how to interpret "negative" biopsies.

Methods

Our study samples were 27 endomyocardial biopsies from 25 patients, three cardiac transplantation and an autopsied heart with suspected cardiac sarcoidosis. Pathologic, radiologic, and clinical features were compared.

Results

The presence of micro-granulomas or increased histiocytic infiltration was always (6/6 or 100%) associated with fatty infiltration and confluent fibrosis, and they showed radiological features of sarcoidosis. Three of five cases (60%

SUBMITTER: Cha MJ 

PROVIDER: S-EPMC7483025 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature