Maternal dietary fat intake and the risk of congenital heart defects in offspring.

ABSTRACT:

Background

Fatty acids are crucial in embryologic development, including cardiogenesis. The impact of maternal periconceptional dietary fat intake on the risk of congenital heart defects (CHDs) has not been clearly elucidated. We hypothesized that maternal dietary fat intake during pregnancy is associated with risk of CHDs in offspring.

Methods

We analyzed CHD cases and nonmalformed controls from the National Birth Defects Prevention Study, a case-control, multicenter population-based study of birth defects. We used multivariable logistic regression to analyze the association between maternal periconceptional dietary fat intake and occurrence of CHDs.

Results

We examined 11,393 infants with CHDs (cases) and 11,029 infants without birth defects (controls). Multivariabl

SUBMITTER: Collins RT 

PROVIDER: S-EPMC7483164 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature