Burst Suppression: Causes and Effects on Mortality in Critical Illness.

ABSTRACT:

Background

Burst suppression in mechanically ventilated intensive care unit (ICU) patients is associated with increased mortality. However, the relative contributions of propofol use and critical illness itself to burst suppression; of burst suppression, propofol, and critical illness to mortality; and whether preventing burst suppression might reduce mortality, have not been quantified.

Methods

The dataset contains 471 adults from seven ICUs, after excluding anoxic encephalopathy due to cardiac arrest or intentional burst suppression for therapeutic reasons. We used multiple prediction and causal inference methods to estimate the effects connecting burst suppression, propofol, critical illness, and in-hospital mortality in an observational retrospective study. We also estim

SUBMITTER: Hogan J 

PROVIDER: S-EPMC7483190 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature