Use of Proton Pump Inhibitors Increases Risk of Incident Kidney Stones.

ABSTRACT:

Background and aims

Proton pump inhibitors (PPIs) are widely prescribed and have effects on gut ion absorption and urinary ion concentrations. PPIs might therefore protect against or contribute to development of kidney stones. We investigated the association between PPI use and kidney stones.

Methods

We performed a retrospective study using data from the Women's Veteran's Cohort Study, which comprised men and women, from October 1, 1999 through September 30, 2017. We collected data from 465,891 patients on PPI usage over time, demographics, laboratory results, comorbidities, and medication usage. Time-varying Cox proportional hazards and propensity matching analyses determined risk of PPI use and incident development of kidney stones. Use of histamine-2 receptor antagonists

SUBMITTER: Simonov M 

PROVIDER: S-EPMC7483196 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature