Sex as a biological variable in the rat model of diisopropylfluorophosphate-induced long-term neurotoxicity.

ABSTRACT: Sex differences in response to neurotoxicant exposure that initiates epileptogenesis are understudied. We used telemetry-implanted male and female adult rats exposed to an organophosphate (OP) neurotoxicant, diisopropylflourophosphate (DFP), to test sex differences in the severity of status epilepticus (SE) and the development of spontaneous recurrent seizures (SRS). Females had significantly less severe SE and decreased epileptiform spikes compared with males, although females received a higher dose of DFP than males. The estrous stages had no impact on seizure susceptibility, but rats with severe SE had a significantly prolonged diestrus. A previously demonstrated disease-modifying agent, an inducible nitric oxide synthase inhibitor, 1400W, was tested in both sexes. None of the eight mal

SUBMITTER: Gage M 

PROVIDER: S-EPMC7483197 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature