Advances in imaging of understudied ions in signaling: A focus on magnesium.

ABSTRACT: The study of metal ions in the context of cell signaling has historically focused mainly on Ca²⁺, the second messenger par excellence. But recent studies support an emerging paradigm in which other metals, including magnesium and d-block metals, play a role in signal transduction as well. Armed with the right indicators, fluorescence microscopy offers a unique combination of spatial and temporal resolution perfectly suited to reveal metal transients in real time, while also helping identify possible sources of ion mobilization and molecular targets. With a focus on Mg²⁺, we highlight recent advancements in the development of molecular indicators and imaging strategies for the study of metal ions in signaling. We discuss remaining conceptual and technical challenges in

SUBMITTER: Lazarou TS 

PROVIDER: S-EPMC7483230 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature