An exploratory analysis on the influence of genetic variants on weight gain among etonogestrel contraceptive implant users.

ABSTRACT:

Objective

To identify genetic variants associated with weight gain related to etonogestrel contraceptive implant use.

Study design

We conducted a retrospective analysis from a parent pharmacogenomic study of healthy, reproductive-aged women using etonogestrel implants. We reviewed medical records to calculate objective weight changes from implant insertion to study enrollment and asked participants about subjective weight gain (yes/no) during contraceptive implant use. We used genotyping data (99 genetic variants) from the parent study to conduct backward-stepwise generalized linear modeling to identify genetic variants associated with objective weight changes.

Results

Among 276 ethnically diverse participants, median body-mass index (BMI) was 25.8 kg/m² (r

SUBMITTER: Lazorwitz A 

PROVIDER: S-EPMC7483263 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature