Inflammatory cytokine and catabolic enzyme expression in a goat model of intervertebral disc degeneration.

ABSTRACT: Intervertebral disc degeneration is implicated as a leading cause of low back pain. Persistent, local inflammation within the disc nucleus pulposus (NP) and annulus fibrosus (AF) is an important mediator of disc degeneration and negatively impacts the performance of therapeutic stem cells. There is a lack of validated large animal models of disc degeneration that recapitulate clinically relevant local inflammation. We recently described a goat model of disc degeneration in which increasing doses of chondroitinase ABC (ChABC) were used to reproducibly induce a spectrum of degenerative changes. The objective of this study was to extend the clinical relevance of this model by establishing whether these degenerative changes are associated with the local expression of inflammatory cytokines and

SUBMITTER: Zhang C 

PROVIDER: S-EPMC7483272 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature