Estimating contextual effect in nonpharmacological therapies for pain in knee osteoarthritis: a systematic analytic review.

ABSTRACT:

Objective

Conduct a systematic review and use meta-analytic techniques to estimate the proportion of total treatment effect that can be attributable to contextual effects (PCE) in adults receiving nonpharmacological, nonsurgical (NPNS) treatments for knee osteoarthritis (OA).

Design

We reviewed the published literature to identify five frequently studied NPNS treatments for knee OA: exercise, acupuncture, ultrasound, laser, and transcutaneous electrical nerve stimulation (TENS). We searched for randomized controlled trials (RCTs) of these treatments and abstracted pre- and post-intervention pain scores for groups receiving placebo and active treatments. For each study we calculated the PCE by dividing the change in pain in the placebo group by the change in pain in the activ

SUBMITTER: Chen AT 

PROVIDER: S-EPMC7483273 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature