Association between muscle mass and insulin sensitivity independent of detrimental adipose depots in young adults with overweight/obesity.

ABSTRACT:

Background/objective

Less muscle mass has been associated with greater insulin resistance, but whether the association is independent of deleterious adipose depots in young adults with overweight/obesity who are at high risk for type 2 diabetes (T2DM) but are otherwise metabolically healthy is not known. The objective of this study was to determine whether muscle mass is independently associated with insulin sensitivity (IS) in young adults with overweight/obesity.

Subjects/methods

Cross-sectional Clinical Research Center study of 132 adults, 21-45yo, BMI ≥ 25 kg/m² and metabolically healthy without T2DM. Primary independent variable: percent ideal appendicular lean mass (ALM) calculated as measured ALM divided by predicted ALM for age, weight, and height, calcula

SUBMITTER: Haines MS 

PROVIDER: S-EPMC7483278 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature