Inherited Risk for Autism Through Maternal and Paternal Lineage.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is highly familial, with a positively skewed male-to-female ratio that is purported to arise from the so-called female protective effect. A serious implication of a female protective effect is that familial ASD liability would be expected to aggregate asymptomatically in sisters of affected probands, who would incur elevated rates of ASD among their offspring. Currently, there exist no data on second-generation recurrence rates among families affected by ASD.

Methods

We analyzed data from the Swedish National Patient Register and the Multi-Generation Register for a cohort of children born between 2003 and 2012. ASD was ascertained in both the child and parental generations.

Results

Among 847,732 children, 13,103 (1.55%) childr

SUBMITTER: Bai D 

PROVIDER: S-EPMC7483301 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature