Frontostriatal white matter connectivity: age differences and associations with cognition and BOLD modulation.

ABSTRACT: Despite the importance of cortico-striatal circuits to cognition, investigation of age effects on the structural circuitry connecting these regions is limited. The current study examined age effects on frontostriatal white matter connectivity, and identified associations with both executive function performance and dynamic modulation of blood-oxygen-level-dependent (BOLD) activation to task difficulty in a lifespan sample of 169 healthy humans aged 20-94 years. Greater frontostriatal diffusivity was associated with poorer executive function and this negative association strengthened with increasing age. Whole-brain functional magnetic resonance imaging (fMRI) analyses additionally indicated an association between frontostriatal mean diffusivity and BOLD modulation to difficulty selectively

SUBMITTER: Webb CE 

PROVIDER: S-EPMC7483315 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature