A preliminary examination of brain morphometry in youth with Down syndrome with and without parent-reported sleep difficulties.

ABSTRACT:

Background

Down syndrome is associated with poor sleep but little is known about its neural correlates.

Aims

The current research compared brain morphometry in youth with Down syndrome with parent-reported sleep problems (DS-S) to peers with Down syndrome (DS) and typical development (TD) without parent-reported sleep problems matched on age (M = 15.15) and sex ratio (62 % female).

Methods and procedures

Magnetic resonance imaging was completed on a 3 T scanner. Participants were stratified into groups based on parent-report: DS-S (n = 17), DS (n = 9), TD (n = 22). Brain morphometry, processed with the FreeSurfer Image Analysis Suite, was compared across groups. In addition, the co-occurrence of medical conditions in the DS groups was examined.

Outcomes and results

SUBMITTER: Lee NR 

PROVIDER: S-EPMC7483358 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature