Assessing effects of oxytocin on alcohol consumption in socially housed prairie voles using radio frequency tracking.

ABSTRACT: Alcohol use disorder affects millions of people each year. Currently approved pharmacotherapies have limited success in treating this disorder. Evidence suggests that this lack of success is partly due to how these pharmacotherapies are tested in preclinical settings. The vast majority of preclinical studies assessing the effects of pharmacotherapies on alcohol or drug self-administration are done in individually housed animals. However, it is known that alcohol and drug intake are heavily influenced by social settings. Here, we adapted radio frequency tracking technology to determine the effects of oxytocin, a potential therapy for alcohol use disorder, on alcohol consumption in socially housed male and female prairie voles. Voluntary alcohol consumption in these animals resulted in high

SUBMITTER: Walcott AT 

PROVIDER: S-EPMC7483374 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature