Modeling the role of incarceration in HCV transmission and prevention amongst people who inject drugs in rural Kentucky.

ABSTRACT:

Background

People who inject drugs (PWID) experience high incarceration rates, with current/recent incarceration being associated with increased hepatitis C virus (HCV) transmission. We assess the contribution of incarceration to HCV transmission amongst PWID in Perry County (PC), Kentucky, USA, and the impact of scaling-up community and in-prison opioid substitution therapy (OST), including the potential for reducing incarceration.

Methods

A dynamic model of incarceration and HCV transmission amongst PWID was calibrated in a Bayesian framework to epidemiological and incarceration data from PC, incorporating an empirically estimated 2.8-fold (95%CI: 1.36-5.77) elevated HCV acquisition risk amongst currently incarcerated or recently released (<6 months) PWID compared to other

SUBMITTER: Stone J 

PROVIDER: S-EPMC7483428 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature