Multicomponent gold nano-glycoconjugate as a highly immunogenic and protective platform against Burkholderia mallei.

ABSTRACT: Burkholderia mallei (Bm) is a facultative intracellular pathogen and the etiological agent of glanders, a highly infectious zoonotic disease occurring in equines and humans. The intrinsic resistance to antibiotics, lack of specific therapy, high mortality, and history as a biothreat agent, prompt the need of a safe and effective vaccine. However, the limited knowledge of protective Bm-specific antigens has hampered the development of a vaccine. Further, the use of antigen-delivery systems that enhance antigen immunogenicity and elicit robust antigen-specific immune responses has been limited and could improve vaccines against Bm. Nanovaccines, in particular gold nanoparticles (AuNPs), have been investigated as a strategy to broaden the repertoire of vaccine-medi

SUBMITTER: Tapia D 

PROVIDER: S-EPMC7483444 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature