Long-term Changes in the Central Amygdala Proteome in Rats with a History of Chronic Cocaine Self-administration.

ABSTRACT: The central nucleus of the amygdala (CeA) is a striatum-like structure that contains mainly inhibitory circuits controlling a repertoire of (mal)adaptive behaviors related to pain, anxiety, motivation, and addiction. Neural activity in the CeA is also necessary for the expression of persistent and robust drug seeking, also termed 'incubation of drug craving.' However, neuroadaptations within this brain region supporting incubated drug craving have not been characterized. Here, we conducted a comprehensive analysis of protein expression in the CeA of male rats after prolonged (45-day) abstinence from extended-access cocaine self-administration using a quantitative proteomic approach. The proteomic analysis identified 228 unique proteins altered in cocaine rats relative to animals that recei

SUBMITTER: Hamor PU 

PROVIDER: S-EPMC7483535 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature