Gene-obesogenic environment interactions on body mass indices for older black and white men and women from the Health and Retirement Study.

ABSTRACT:

Background

Gene-obesogenic environment interactions influence body mass index (BMI) across the life course; however, limited research examines how these interactions may differ by race and sex.

Methods

Utilizing mixed-effects models, we examined the interaction effects of a polygenic risk score (PGS) generated from BMI-associated single-nucleotide polymorphisms, and environmental factors, including age, physical activity, alcohol intake, and childhood socioeconomic status on measured longitudinal BMI from the Health and Retirement Study (HRS). HRS is a population representative survey of older adults in the United States. This study used a subsample of genotyped Black (N = 1796) and White (N = 4925) men and women (50-70 years) with measured BMI.

Results

Higher PGS was

SUBMITTER: Thompson MD 

PROVIDER: S-EPMC7483541 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature