Relationship of Parieto-Occipital Brain Energy Phosphate Metabolism and Cognition Using ³¹P MRS at 7-Tesla in Amnestic Mild Cognitive Impairment.

ABSTRACT:

Background

The human brain has high energy requirements that continuously support healthy neuronal activity and cognition. A disruption in brain energy metabolism (BEM) may contribute to early neuropathological changes such as accumulation of β-amyloid and tau in vulnerable populations. One such population is amnestic mild cognitive impairment (aMCI) where some individuals are at risk for developing dementia, i.e. Alzheimer's disease (AD). Recent advances in imaging technology are providing new avenues to measure BEM accurately using 31phosphorus magnetic resonance spectroscopy (31P MRS) at ultra-high-field (UHF) magnetic strength 7-Tesla. This study investigates whether a methodology using partial volume-coil 31P MRS at 7T over parieto-occipital lobes can accurately quantify high-

SUBMITTER: Das N 

PROVIDER: S-EPMC7483543 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature