Targeted manipulation of pain neural networks: The potential of focused ultrasound for treatment of chronic pain.

ABSTRACT: Focused ultrasound (FUS) is a promising technology for facilitating treatment of brain diseases including chronic pain. Focused ultrasound is a unique modality for delivering therapeutic levels of energy into the body, including the central nervous system (CNS). It is non-invasive and can target spatially localized effects through the intact skull to cortical or subcortical regions of the brain. FUS can achieve three different mechanisms of action in the brain that are relevant for chronic pain treatment: (1) localized thermal ablation of neural tissue; (2) localized and transient disruption of the blood-brain barrier for targeted drug delivery to CNS structures; and (3) inhibition or stimulation of neuronal activity in targeted regions. This review provides an in-depth look at the technol

SUBMITTER: Todd N 

PROVIDER: S-EPMC7483565 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature