A Genetic Risk Score to Personalize Prostate Cancer Screening, Applied to Population Data.

ABSTRACT:

Background

A polygenic hazard score (PHS), the weighted sum of 54 SNP genotypes, was previously validated for association with clinically significant prostate cancer and for improved prostate cancer screening accuracy. Here, we assess the potential impact of PHS-informed screening.

Methods

United Kingdom population incidence data (Cancer Research United Kingdom) and data from the Cluster Randomized Trial of PSA Testing for Prostate Cancer were combined to estimate age-specific clinically significant prostate cancer incidence (Gleason score ≥7, stage T3-T4, PSA ≥10, or nodal/distant metastases). Using HRs estimated from the ProtecT prostate cancer trial, age-specific incidence rates were calculated for various PHS risk percentiles. Risk-equivalent age, when someone with a giv

SUBMITTER: Huynh-Le MP 

PROVIDER: S-EPMC7483627 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature